Immunomodulatory effect of a proanthocyanidin-rich extract from Pinus radiata bark by dosing period in chickens.
نویسندگان
چکیده
We evaluated the immunomodulatory effects of a proanthocyanidin-rich extract (PAE) from Pinus radiata bark in Korean native chickens. In experiment 1, proliferation of peripheral blood mononuclear cells was significantly enhanced in chickens administered 1.25, 2.5, 5, and 10 mg/kg of PAE for 2 wk once daily by oral gavage compared with no administration of PAE in vitro. Proliferation of splenocyte and thymocyte cells was also significantly enhanced in chickens administered 1.25, 2.5, 5, and 10 mg/kg of PAE for 5 wk. In experiment 2, proliferation of peripheral blood mononuclear cells, splenocytes, and thymocytes in chickens administered PAE for 6 wk was continuously higher than that in other groups. Additionally, increasing cell populations for which CD4(+)CD8(-)(Th cells) and Bu-1(+) (B cells) protein was expressed on the cell surface were significantly different after 4 wk of PAE administration in chickens. Thus, the immunomodulatory effects of a PAE from P. radiata bark differed by dosing period in chickens.
منابع مشابه
Effect of pine bark (Pinus radiata) extracts on sporulation of coccidian oocysts.
A series of experiments have been undertaken to determine the effect of water extracts from pine bark (Pinus radiata) on the inhibition of the sporulation of oocysts of three species of avian coccidia. Tubes containing coccidian oocysts isolated from droppings of coccidia-infected chickens were randomly assigned to 0, 250, 500 and 1000 microg/ml pine bark extract (PBE). The tubes were incubated...
متن کاملEfficacy of Pinus radiata bark extract and vitamin C combination product as a prophylactic therapy for recalcitrant migraine and long-term results.
PURPOSE This was the open-label study to evaluate the potential benefit of Pinus radiata bark extract and vitamin C as a treatment for migraine. METHODS Fifty outpatients with chronic migraine refractory to at least two prophylactic medications were treated with an antioxidant formulation of 1200 mg Pinus radiata bark extract and 150 mg vitamin C daily for 3 months. Patients completed migrain...
متن کاملEFFECT OF THE BENCH SCALE EXTRACTION CONDITIONS ON Pinus radiata BARK EXTRACT YIELD, ANTIOXIDANT PROPERTIES AND COMPOSITION
Many pine bark extracts have antioxidant properties. This work examined bench scale extraction on the yield, the composition and antioxidant properties of Pinus radiata. Acetone solvent (98.7% w/w at 120 °C) yielded maximum phenols concentration, tannins concentration, anti-radical activity (DPPH) and reducing activity (FRAP), although its extraction yield was the lowest. When the organic solve...
متن کاملCytoprotective Effect of Hydroalcoholic Extract of Pinus eldarica Bark against H2O2-Induced Oxidative Stress in Human Endothelial Cells
Background: Pinus eldarica is a widely growing pine in Iran consisting of biologically active constituents with antioxidant properties. This study investigates the effect of hydroalcoholic extract of P. eldarica bark against oxidative damage induced by hydrogen peroxide (H2O2) in human umbilical vein endothelial cells (HUVECs). Methods: The total phenolic content of p. eldarica extract was dete...
متن کاملPyrolysis Products of Pinus Radiata Bark
The yields of char, tar, and non-condensible gases from the pyrolysis of Pinus radiata D. Don bark were measured. Pyrolysis of bark, on a small preparative scale using an airacetylene flame, gave 48% char with ash content 3.5% (mainly aluminium, calcium, potassium, and silica), and recovered tar in 7% yield (on oven-dried bark equivalent). The major components of the pyrolysis tar were catechol...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Poultry science
دوره 92 2 شماره
صفحات -
تاریخ انتشار 2013